Certified Registered Nurse Infusion (CRNI) 2025 – 400 Free Practice Questions to Pass the Exam

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What substance is used to protect frozen red cells during storage?

Sorbitol

Glycerol

Glycerol is employed as a protective agent for frozen red blood cells during storage due to its ability to stabilize cell membranes and prevent damage caused by the formation of ice crystals. When red blood cells are frozen, ice crystals can disrupt the cellular structure, leading to loss of viability upon thawing. Glycerol works by penetrating the red blood cells and replacing water in the cell, thereby reducing the volume of water available to form ice crystals and maintaining cell integrity.

This protective role is crucial in cryopreservation, where red blood cells can be stored for extended periods. Glycerol's properties make it particularly suitable for this purpose, allowing for a successful recovery of the cells post-thaw.

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Cellulose

Glucose

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